2020
Operation Warp Speed: mRNA Vaccines
operation-warp-speed-mrna-vaccines
2012
CAR-T Cell Therapy
car-t-cell-therapy
2003
PEPFAR
pepfar
2003
Human Genome Project
human-genome-project
1988
Laparoscopy
laparoscopy
1987
Statins
statins
1980
MRI
mri
1977
PET Scan
pet-scan
1977
Global Eradication of Smallpox
global-eradication-of-smallpox
1976
Genentech & the Birth of Biotech
genentech-the-birth-of-biotech
1973
Telemedicine
telemedicine
1967
Coronary Bypass Surgery
coronary-bypass-surgery
1961
Framingham Heart Study
framingham-heart-study
1955
The Polio Vaccine
the-polio-vaccine
1954
Kidney Transplant
kidney-transplant
1952
Eternal Pacemaker
eternal-pacemaker
1944
Penicillin Scale-Up
penicillin-scale-up
1944
DNA vs. Protein
dna-vs-protein
1937
Blood Banking, A System for Stored Lifesaving
blood-banking-a-system-for-stored-lifesaving
1923
Insulin Mass Production
insulin-mass-production
1862
The Civil War Ambulance Corps and Birth of the Modern EMS
the-civil-war-ambulance-corps-and-birth-of-the-modern-ems
1846
Ether Anesthesia
ether-anesthesia
1820
Establishing Pharmacopeia
establishing-pharmacopeia
1777
Smallpox Inoculation
smallpox-inoculation
1751
Pennsylvania Hospital
pennsylvania-hospital

1955

The Polio Vaccine

As a parent, I can barely imagine the scale of the terror of polio. Historians note that fear of polio was second only to atomic warfare in parents' fears for their children.

At its peak in 1952, polio struck nearly 60,000 children in a single year. The surge in cases catalyzed national mobilization. To validate the science behind a potential cure, Dr. Jonas Salk marshaled the largest field trial in history, mobilizing 1.8 million Polio Pioneers to prove the innovation worked.

The University of Michigan announced the Salk vaccine was "safe, potent, and effective.”

  • Nightmare
    Before this moment, polio was an annual summer nightmare, typically striking children under age 10. In 1952 alone, 21,000 Americans suffered permanent paralysis.
  • Discovery
    Salk pioneered a killed-virus approach. By using an inactivated virus rather than a weakened live one, he created a safer path to immunization that could be manufactured at industrial scale.
  • Strategy
    Salk and the University of Pittsburgh chose not to patent the vaccine. By removing the owner, they invited every manufacturer in America to join the mission without legal friction, allowing mass testing and ultimately, production.
  • Scale
    In 1954, nearly two million schoolchildren volunteered for the trials, the largest peacetime mobilization of civilians in U.S. history.
  • Impact
    Within a decade, U.S. paralytic cases dropped by >95%. As of 2025, polio has been eradicated in all but two countries, preventing over 16 million cases of paralysis globally.

From Brian

Research, discovery, and delivery of new drugs at scale is incredibly expensive. As investors, we have to acknowledge the significant financial and moral tensions inherent in moving a proprietary breakthrough to public availability.

The story of the Polio vaccine is one illustration of the relationship between the sources of capital and the cost of innovation. Salk’s work was almost entirely funded by the National Foundation for Infantile Paralysis (now the March of Dimes), a grassroots engine powered by the literal dimes of millions of ordinary citizens.

The investors were the American people themselves, Salk and the University of Pittsburgh viewed the resulting IP as a public asset.

This attribution isn’t always possible or even advisable, but Salk’s selflessness and clarity in this case provoked a profound advance in global health.

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