2020
Operation Warp Speed: mRNA Vaccines
operation-warp-speed-mrna-vaccines
2012
CAR-T Cell Therapy
car-t-cell-therapy
2003
PEPFAR
pepfar
2003
Human Genome Project
human-genome-project
1988
Laparoscopy
laparoscopy
1987
Statins
statins
1980
MRI
mri
1977
PET Scan
pet-scan
1977
Global Eradication of Smallpox
global-eradication-of-smallpox
1976
Genentech & the Birth of Biotech
genentech-the-birth-of-biotech
1973
Telemedicine
telemedicine
1967
Coronary Bypass Surgery
coronary-bypass-surgery
1961
Framingham Heart Study
framingham-heart-study
1955
The Polio Vaccine
the-polio-vaccine
1954
Kidney Transplant
kidney-transplant
1952
Eternal Pacemaker
eternal-pacemaker
1944
Penicillin Scale-Up
penicillin-scale-up
1944
DNA vs. Protein
dna-vs-protein
1937
Blood Banking, A System for Stored Lifesaving
blood-banking-a-system-for-stored-lifesaving
1923
Insulin Mass Production
insulin-mass-production
1862
The Civil War Ambulance Corps and Birth of the Modern EMS
the-civil-war-ambulance-corps-and-birth-of-the-modern-ems
1846
Ether Anesthesia
ether-anesthesia
1820
Establishing Pharmacopeia
establishing-pharmacopeia
1777
Smallpox Inoculation
smallpox-inoculation
1751
Pennsylvania Hospital
pennsylvania-hospital

1751

Pennsylvania Hospital

As we reflect on America at 250, we can see moments when this country, still young and unfinished, quietly changed the world. In 1751, Thomas Bond and Benjamin Franklin founded Pennsylvania Hospital just as observation-based medicine took hold.

It emphasized clinical observation and shared learning, turning individual care into repeatable knowledge and helped define the academic medical center.

Benjamin Franklin and Thomas Bond founded Pennsylvania Hospital to serve Philadelphia’s most vulnerable.

  • Innovation for all
    They adopted emerging medical practices, formally linking patient care with medical training.
  • Bedside learning
    Doctors trained on real patients, not textbooks alone.
  • Systematic medicine
    Observation and records turned individual care into shared knowledge.
  • Built to scale
    Care, teaching, and inquiry in one place spread better practice faster.
  • Enduring model
    A colonial hospital that helped scale innovative medicine.

From Brian

Pennsylvania Hospital showed us how care could become something that learns, improves, and spreads.

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